In this episode of his podcast, Joe Rogan interviews longevity scientist Dr. David Sinclair. Sinclair is the author of the recently published book Lifespan: Why We Age -- and Why We Don’t Have To. He also is a Professor of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School.
In the first few minutes of the interview, Sinclair gives a quick update on the research that he has been conducting at the leading-edge of longevity science He also shares a bit about his personal longevity protocol, which includes resveratrol & NAD, among others.
Here are some of the key highlights:
Is Aging Truly Reversible?
Sinclair shares details on a preliminary trial in humans that showed how a treatment with a cocktail of growth hormone (GH), DHEA and metformin can partiallyreversebiological age. The results of the trial, led by Dr. Gregory Fahy, were that on average the participants shed 2.5 years of their biological ages. Although the study was small\, Sinclair is optimistic that“one day we could be 80 [chronologically], but be 30 biologically.”.
Measuring Your Biological Age
Sinclair explains how we can now measure biological age with outstanding precision. This is a measurement of how old we are “inside” based on various biomarkers. Our biological and chronological ages can diverge due to lifestyle and other health factors.
One of the most common tools used to calculate biological age is known as the “Horvath clock”, also called an epigenetic clock. It is a methodology that allows scientists to track chemical modifications in DNA (i.e. methylations) that accumulate in a linear, and therefore, predictable way.
“The good news is that now we know that it’s not just measuring aging, we actually think that clock is actually part of the aging process. If we can move the hands of the clock backwards we can reverse the process of aging.”
The Rise of NAD Supplements Over Antioxidants as a protocol for longevity.
Sinclair explains how antioxidants, despite great expectations, have largely failed to extend the lifespan of any organism. Better studied biomarkers and other hallmarks of aging are now pointing in a different direction. Leading the charge is the role of NAD+ and its precursors (NMN), which help activate sirtuin genes, all of which are related to longevity.
Other Key Takeaways
- The reason he takes Resveratrol, but never with water
- His personal implementation of intermittent fasting
- How he balances the dichotomy between the anti-aging effects of metformin and the loss of performance by taking it only when he is not exercising
- Why high cholesterol might not be necessarily a bad thing, especially if you are not sedentary and have the appropriate ratio of HDL to LDL
- How genetic engineering with CRISPR will revolutionize medicine